3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis
نویسندگان
چکیده
منابع مشابه
1-(3-Chlorobenzyloxy)urea
The asymmetric unit of the crystal structure of the title compound, C(8)H(9)ClN(2)O(2), contains four independent mol-ecules. The dihedral angles between the urea N-(C=O)-N planes and the benzene rings are 83.3 (3), 87.8 (1), 89.1 (1) and 17.5 (2)° in the four mol-ecules. Extensive N-H⋯O hydrogen bonding is present in the crystal structure.
متن کامل1-(3-Phenylpropyl)urea
In the crystal of the title compound, C(10)H(14)N(2)O, double supra-molecular layers of PhCH(2)CH(2)CH(2)NHC(O)NH(2) are formed parallel to the bc plane by inter-molecular N-H⋯O hydrogen bonding, with R(2) (2)(8) and R(2) (1)(6) motifs in the b- and c-axis directions, respectively. The mean plane of the C(ar)-C-C group makes a dihedral angle of 84.8 (2)° with the benzene ring.
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We examined the effect of urea on NaK2Cl cotransport in human erythrocytes. In erythrocytes from nine normal subjects, the addition of 45 mM urea, a concentration commonly encountered in uremic subjects, inhibited NaK2Cl cotransport by 33 +/- 7%. Urea inhibited NaK2Cl cotransport reversibly, and in a concentration-dependent fashion with half-maximal inhibition at 63 +/- 10 mM. Acute cell shrink...
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The synthesis of citrulline from ornithine and arginine from citrulline has heretofore been associated only with intact liver cells. In the course of studies on the mechanism of the conversion of citrulline to a&nine, a highly active system was found in liver homogenate capable of forming urea in the presence of glutamic acid, adenosine triphosphate (ATP), cytochrome c, an oxygen atmosphere, an...
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A method for measuring urea production by isolated erythrocytes and leucocytes under physiologic conditions is described. Erythrocytes from 10 normal subjects formed an average of 82.5 mmoles urea/mi. packed cells/hr. Leucocytes formed 7.4 mmoles urea/108 cells/hr. By extrapolation, total urea synthesis by circulating erythrocytes would be approximately 270 mg./day and by the granulocyte pool a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m800163200